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Electro-generation of single femtoliter- and picoliter-volume aqueous droplets in microfluidic systems

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3 Author(s)
He, Mingyan ; Department of Chemistry, University of Washington, Seattle, Washington 98195-1700 ; Kuo, Jason S. ; Chiu, Daniel T.

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This letter presents a new method to generate individual femtoliter- to picoliter-volume aqueous droplets in oil using single voltage pulses. With high-speed imaging, we characterized the displacement of the water-oil interface as a function of the time and amplitude of the voltage pulse. At high voltages where jetting and droplet formation occurred, we observed the ratio of droplet-to-jet diameter to be ∼1.84, which suggested Rayleigh instability as the primary mechanism responsible for droplet breakup. Droplets with volumes ranging from 14 fl to 8 pl were produced using this method.

Published in:

Applied Physics Letters  (Volume:87 ,  Issue: 3 )

Date of Publication:

Jul 2005

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