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This paper presents the design procedure for complex RF circuits using the Jumping Genes Evolutionary Algorithm (JGEA). Due to the complex and stringent requirements for industrial environments, it is not an easy task to obtain a good design in which irregular structures are always needed. In this paper, JGEA has, however, demonstrated its excellent ability in practical RF circuit design compared with other algorithms. For demonstration, it was used in the design of a slot-coupled 3-dB hybrid coupler operating in the popular Industrial, Scientific and Medical application frequency band with small amplitude imbalance, low cost, and small size.