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This brief addresses the optimal-stabilization problem for networked control systems (NCSs) with time delays and packet losses. The closed-loop NCS is modeled as a discrete-time switched system, and the stability conditions are derived in terms of linear matrix inequality. A controller design method with both system stability and control performance taken into account is proposed, and estimation of distribution algorithm is used to select the optimal stabilizing gain. The proposed method can be easily implemented to various applications, since it has simple structure and has no assumptions on time-delay and packet-loss models. Simulation and experimental results are given to demonstrate the effectiveness of the proposed approach.