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Fabrication of Biodegradable Microcapsules Utilizing 3D, Surface Modified PDMS Microfluidic Devices

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2 Author(s)
Liao, C.Y. ; Dept. of Eng. & Syst. Sci., Nat. Tsing Hua Univ., Hsinchu ; Su, Y.C.

We have successfully demonstrated the fabrication of biodegradable and magnetic microcapsules utilizing PDMS double emulsification devices. Specially designed 3D microfluidic channels with surface modified by a self-aligned photo-grafting process are employed to shape immiscible fluids into monodisperse W/O/W emulsions. By varying the outer and inner fluid flow-rates, the overall and core sizes of the resulting double emulsions can be adjusted accordingly. Biodegradable materials and surface-treated gamma-Fe2O3 nanoparticles are dispersed uniformly in the middle organic phase, and solidified into magnetic microcapsules once the solvent is extracted. In the prototype demonstration, microcapsules made up of poly(L-lactic acid), trilaurin and phosphocholine (DOPC) are successfully fabricated. As such, the proposed PDMS micro-devices could potentially serve as versatile encapsulation tools, which are desired for a variety of biological and pharmaceutical applications.

Published in:

Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on

Date of Conference:

25-29 Jan. 2009

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