By Topic

In vitro evaluation of ultrasound-assisted thrombolysis using targeted ultrasound contrast agents

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Jia-Ling Ruan ; Dept. of Electr. Eng., Nat. Taiwan Univ., Taipei ; Po-Wen Cheng ; Suz-Chia Chen ; Yueh-Hsun Chuang
more authors

The thrombus-targeted ultrasound contrast agent with tirofiban, a glycoprotein IIb/IIIa antagonist that can specifically bind to activated platelets in the thrombus, was designed to enhance both the image contrast and the cavitation effect. The targeting ability to thrombi was confirmed by microphotography and high frequency ultrasound (40 MHz) images (3.34plusmn0.30 dB enhancement). Our inertial cavitation induction system showed that the enhancement of percent weight loss was about 10%, and it was further examined by using a microscope. We conclude that the targeted microbubbles are applicable not only for molecular imaging of thrombus but also improving effectiveness of ultrasound-assisted thrombolysis.

Published in:

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Date of Conference:

2-5 Nov. 2008