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Intravascular ultrasound mediated delivery of DNA via microbubble carriers to an injured porcine artery in vivo

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5 Author(s)
Phillips, L.C. ; Dept. of Biomed. Eng., Univ. of Virginia, Charlottesville, VA ; Klibanov, A.L. ; Wamhoff, B.R. ; Hossack, J.A.
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Millions of stents are implanted worldwide each year in patients with atherosclerotic arteries. Safety concerns relating to drug eluting stents have spurred interest in alternative vessel therapies. We hypothesized that a reporter gene could be delivered to a porcine coronary artery via intravascular ultrasound (IVUS) and plasmid-coupled microbubbles. In vitro delivery resulted in 0.17% of cells exhibiting successful transfection. An anesthetized porcine underwent balloon angioplasty on a coronary artery. Microbubble injection and rupture were controlled at the injury site using a modified intravascular ultrasound catheter. At 3 days post-insonation, gene expression was localized at injured vessel sites in (23.3% of luminal cells) with minimal expression in control arteries (3.6% of luminal cells). Our results demonstrate that IVUS has promise for localized intra-vascular gene therapy and may potentially offer a novel method for preventing restenosis.

Published in:

Ultrasonics Symposium, 2008. IUS 2008. IEEE

Date of Conference:

2-5 Nov. 2008

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