By Topic

Molecular focusing of high-intensity ultrasound: Time-reversal focusing applied to targeted ultrasound contrast agents

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Olivier Couture ; Laboratoire Ondes et Acoustique, École Supérieure de Physique et Chimie Industrielle, Paris, France ; Jean-Francois Aubry ; Mickael Tanter ; Mathias Fink

Targeted microbubbles bind specifically to molecular markers of diseases and their unique acoustic signature is used to image cellular processes in-vivo. The ability of time reversal processing to focus waves through heterogeneities on such targeted microbubbles is demonstrated. For this purpose, microbubbles were deposited on a gelatin phantom and their specific signal was recorded by a high intensity ultrasonic array. The amplified time-reversed signal was reemitted and shown to focus back in the region where the bound microbubbles were present. This proof of concept emphasizes that molecular-time-reversal focusing could guide energy deposition on early, diffuse or metastatic disease.

Published in:

2008 IEEE Ultrasonics Symposium

Date of Conference:

2-5 Nov. 2008