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The power control and the Hybrid Automatic Repeat Request (HARQ) are important techniques in Wideband Code Division Multiple Access (WCDMA) systems. The joint use of these two mechanisms can enable wireless systems to increase throughput and spectral efficiency. In this paper, we will evaluate the performance of the SIR-based power control in a WCDMA Enhanced Uplink system with a turbo coded HARQ technique over multi-path fading channel. We propose, also, an improved Signal-to-Interference power Ratio (SIR) estimation scheme. In the proposed scheme, the SIR is estimated by using the Enhanced Dedicated Physical Data Channel (E-DPDCH) instead of using the Dedicated Physical Control Channel (DPCCH).