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Reduced-reference image quality assessment (RRIQA) methods estimate image quality degradations with partial information about the ldquoperfect-qualityrdquo reference image. In this paper, we propose an RRIQA algorithm based on a divisive normalization image representation. Divisive normalization has been recognized as a successful approach to model the perceptual sensitivity of biological vision. It also provides a useful image representation that significantly improves statistical independence for natural images. By using a Gaussian scale mixture statistical model of image wavelet coefficients, we compute a divisive normalization transformation (DNT) for images and evaluate the quality of a distorted image by comparing a set of reduced-reference statistical features extracted from DNT-domain representations of the reference and distorted images, respectively. This leads to a generic or general-purpose RRIQA method, in which no assumption is made about the types of distortions occurring in the image being evaluated. The proposed algorithm is cross-validated using two publicly-accessible subject-rated image databases (the UT-Austin LIVE database and the Cornell-VCL A57 database) and demonstrates good performance across a wide range of image distortions.