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This paper presents design and linearization techniques for a highly efficient, but nonlinear Class-E power amplifier (PA) applied to linear RF transmitters. To achieve maximum efficiency for Class-E PA operating above gigahertz frequencies, the proposed design theory modifies the classic Class-E condition and considers switch-on and switch-off resistances in deriving the analytical solution. For linearization, a digital envelope predistorter (DEP) is used to provide predistorted envelope modulation for the RF-input and supply-voltage signals fed to the Class-E PA. This DEP can successfully compensate for AM/AM and AM/PM distortions such that the Class-E PA, although classified as a switching-mode PA, can act as a linear PA. A cdma2000 1 times transmitter incorporating this Class-E PA and DEP is demonstrated to simultaneously achieve high efficiency and high modulation quality.