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Game between different enterprises in the food chain plays important roles in the food quality. This paper applies the games theory to develop a food supply chain quality management model and describes the implementation algorithm of model. The simulation result shows that the model can simply solve the problem of the optimum quality management in the condition of changing external demand, at this time the largest profit can be obtained, meanwhile, the state of food quality level in whole food supply chain is optimum. Therefore, it is essential for us to take some measures to perfecting reward and punishment mechanism. It can reduce asymmetry information overcome market failures in the food chain, as well as can be traced back and resolve the question from the source once there are some quality problems.