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In this paper, we introduce a novel approach to interference cancellation (IC) for code division multiple access (CDMA) uplink transmission. Several models combining principles of serial (SIC) and parallel (PIC) interference cancellation are discussed. The proposed scheme is derived from the analysis of these hybrid models and applies a user configuration algorithm (termed ldquotricklerdquo) in order to provide improved bit-error-rate (BER) performance. The algorithm utilizes an adaptive matrix to compute the required configuration to be used for the subsequent interference cancellation stage. We demonstrate that significant performance improvements can be achieved over various hybrid schemes. A reduced-complexity version of the trickle algorithm is also introduced where the processing delay is greatly reduced while maintaining similar performance. We present several numerical examples through which we demonstrate the efficacy of the proposed algorithms relative to existing interference cancellation algorithms.