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The DS-CDMA signal model and the noisy linear independent component analysis (ICA) model are analyzed in this paper. Comparing these models shows that they have the same form. The adaptive minimum mean-square error (MMSE) multiuse detection based on ICA is proposed. It uses the output of adaptive MMSE multi-user detection to initialize the ICA iterations, not only the known spread information of interesting user is used to overcome the uncertainness of ICA, but also the character of statistical independence is used. The simulation results show that the performance is improved obviously.