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This brief considers the problem of fault detection (FD) for a class of nonlinear networked control systems (NCSs) in which the sensors and actuators of the plant exchange information with a remote controller via a shared communication medium. Under the model utilized here, the communication cannot transfer all the information that sensors or controllers send. The choice of sensors and actuators that are active is designed to achieve the reachability and observability of the NCS. A novel method is proposed for the FD of a nonlinear NCS by first identifying a pair of communication sequences that preserve reachability and observability and then designing an observer-based FD based on those sequences. An example is given to show the potential of the proposed techniques.