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Studying biologically inspired systems had received a great interest in few last years. Artificial neural networks, evolutionary computation, DNA computation, and artificial immune systems are some of the researcher interest which can be highlighted. The human immune system (HIS) is a compound of molecules, cells, and organs which has established to perform several tasks; imperfect detection, distributed detection, adaptability, and generation of diversity, recognition, learning, memory acquisition, generalization, and optimization. New computational techniques are being developed basing on the immune system concepts, seeking to solve several engineering problems. Moreover, mobile ad hoc networks (MANETs) have no clear line of defense and no fixed infrastructure; therefore, the known security techniques used for cabled networks might not work perfectly. A security architecture based on both immunity and multi-agent paradigm is presented. Distributability, second response, and self recovery, are the hallmarks of the proposed security model which places emphasis on high nodes mobility.