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We report here a novel approach called microelectromechanical systems (MEMS) microflex interconnect (MMFI) technology for packaging a new generation of bioMEMS devices that involve movable microelectrodes implanted in brain tissue. MMFI addresses the need for the following: (1) operating space for movable parts and (2) flexible interconnects for mechanical isolation. We fabricated a thin polyimide substrate with embedded bond pads, vias, and conducting traces for the interconnect with a backside dry etch, so that the flexible substrate can act as a thin-film cap for the MEMS package. A double-gold-stud-bump rivet-bonding mechanism was used to form electrical connections to the chip and also to provide a spacing of approximately 15-20 mum for the movable parts. The MMFI approach achieved a chip-scale package that is lightweight and biocompatible and has flexible interconnects and no underfill. Reliability tests demonstrated minimal increases of 0.35, 0.23, and 0.15 mOmega in mean contact resistances under high humidity, thermal cycling, and thermal shock conditions, respectively. High-temperature tests resulted in increases of > 90 and ~ 4.2 mOmega in resistance when aluminum and gold bond pads were used, respectively. The mean time to failure was estimated to be at least one year under physiological conditions. We conclude that MMFI technology is a feasible and reliable approach for packaging and interconnecting bioMEMS devices.