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Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow

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6 Author(s)
Kairong Qin ; Institute of Mechanobiology and Medical Engineering, Shanghai Jiao Tong University, 200240, China ; Zhe Xu ; Hui Zhang ; Cheng Xiang
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In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface

Published in:

2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control

Date of Conference:

4-6 Oct. 2006