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Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow

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6 Author(s)
Kairong Qin ; Inst. of Mechanobiology & Med. Eng., Shanghai Jiao Tong Univ. ; Zhe Xu ; Hui Zhang ; Cheng Xiang
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In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface

Published in:

Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control, 2006 IEEE

Date of Conference:

4-6 Oct. 2006

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