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Product quality is a major concern for manufacturing enterprises, so it is of key importance to monitor and control the soundness and effectiveness of production systems. Centralized and hierarchical control architectures that characterized by strong master-slave relationships is still widely used. But with the increasing complexity of the production system and the products itself, quality control for CPS (Complex Production System) becomes more and more difficult. Based on the analysis of quality system requirement for CPS, we found that autonomic system is a potentially useful quality paradigm for CPS. But a completely decentralized solution is unstable and prohibitively complex. A compromise has to be found. This paper draws inspiration from biological immune system to learn valuable lessons for autonomic manufacturing defense system. Important immunological metaphors, such as feature extraction, learing, memory, and its distributive nature are utilized to adapt to the new requirements of quality system for CPS.