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Physical Properties of Hydrogel Prepared from Stereo Complex of Star-Shaped PEG-Polylactide Block Copolymers Exhibiting Temperature-Responsive Sol-Gel Transition as Cellular Scaffold for Tissue Engineering

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4 Author(s)
Ohya, Y. ; Dept. of Chem. & Mater. Eng., Kansai Univ., Suita ; Fujiura, K. ; Nagahama, K. ; Ouchi, T.

Starburst triblock copolymers consisting of 8-arm poly(ethylene glycol) (8-arm PEG), poly(L-lactide) (PLLA) or its enantiomer poly(D-lactide) (PDLA) and terminal PEG, 8-arm PEG-b-PLLA-b-PEG (Stri-L) and 8-arm PEG-b-PDLA-b-PEG (Stri-D), were synthesized. An aqueous solution of a 1:1 mixture (Stri-Mix) of Stri-L and Stri-D assumed a sol state at room temperature, but instantaneously formed a physically cross-linked hydrogel in response to increasing temperature. The resulting hydrogel exhibited a high storage modulus at 37degC. The rapid temperature-triggered hydrogel formation, high mechanical strength, and degradation behavior render this polymer system suitable for use in injectable drug delivery system or a biodegradable scaffold for tissue engineering.

Published in:

Micro-NanoMechatronics and Human Science, 2008. MHS 2008. International Symposium on

Date of Conference:

6-9 Nov. 2008