By Topic

Physical Properties of Hydrogel Prepared from Stereo Complex of Star-Shaped PEG-Polylactide Block Copolymers Exhibiting Temperature-Responsive Sol-Gel Transition as Cellular Scaffold for Tissue Engineering

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Yuichi Ohya ; Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, & High-Technology Research Center, Kansai University 3-3-35 Yamate, Suita, Osaka 564-868 Japan ; Kanae Fujiura ; Koji Nagahama ; Tatsuro Ouchi

Starburst triblock copolymers consisting of 8-arm poly(ethylene glycol) (8-arm PEG), poly(L-lactide) (PLLA) or its enantiomer poly(D-lactide) (PDLA) and terminal PEG, 8-arm PEG-b-PLLA-b-PEG (Stri-L) and 8-arm PEG-b-PDLA-b-PEG (Stri-D), were synthesized. An aqueous solution of a 1:1 mixture (Stri-Mix) of Stri-L and Stri-D assumed a sol state at room temperature, but instantaneously formed a physically cross-linked hydrogel in response to increasing temperature. The resulting hydrogel exhibited a high storage modulus at 37degC. The rapid temperature-triggered hydrogel formation, high mechanical strength, and degradation behavior render this polymer system suitable for use in injectable drug delivery system or a biodegradable scaffold for tissue engineering.

Published in:

Micro-NanoMechatronics and Human Science, 2008. MHS 2008. International Symposium on

Date of Conference:

6-9 Nov. 2008