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Scatter corrections for simultaneously acquired dual-isotope SPECT imaging using three windows

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6 Author(s)
Sunyoung Jang ; Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA ; Jaszczak, R.J. ; Li, J. ; Lowe, V.J.
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The authors investigated the feasibility of using a third energy window (EW) for rest 201Tl/stress 99mTc scatter corrections in order to obtain improved quantification and image quality compared with dual-isotope myocardial perfusion imaging using two photopeak energy windows (PEWs). Three low energy ultra-high resolution parallel beam collimators were mounted on a triple-camera SPECT system and used to obtain planar and SPECT images. To obtain the relationships between the intermediate EW (IEW) and dual-isotope scatter EWs (SEWs), five different EWs, including an IEW (103 keV±22%) between the dual-isotope PEWs, were used. Then, the scatter subtraction coefficients obtained from line source measurements with an anthropomorphic phantom were applied to the IEW's scatter correction. The IEW was used for the scatter correction for both isotopes. The crosstalk into each PEW measured with a cardiac phantom was similar in air; however, in water 99mTc to 201Tl crosstalk was greater than twice of that in air. After attenuation and scatter compensation, the quantitative analysis and image quality were improved compared with dual-isotope imaging which used two PEWs, especially with 201Tl scans acquired in the presence of background activity. These results demonstrate that the IEW may be used for dual-isotope scatter compensation, and three window acquisition provides improved myocardial SPECT imaging in an anthropomorphic phantom

Published in:

Nuclear Science Symposium and Medical Imaging Conference, 1994., 1994 IEEE Conference Record  (Volume:4 )

Date of Conference:

30 Oct-5 Nov 1994