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Heterogeneity of SPECT bull's-eyes in normal dogs: comparison of attenuation compensation algorithms

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8 Author(s)
DiBella, E.V.R. ; Dept. of Electr. Eng., Georgia Inst. of Technol., Atlanta, GA, USA ; Eisner, R.L. ; Schmarkey, L.S. ; Barclay, A.B.
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In normal dogs, SPECT Tc-99m Sestamibi (MIBI) Tl-201 myocardial perfusion images reconstructed with filtered backprojection (FBP) show a large decrease of counts in the septal wall (S) compared to the lateral wall (L). We evaluated the iterative method of Chang at 0 and 1 iterations (Chang0 and Chang1), and the Maximum Likelihood-Expectation Maximization with attenuation compensation (ML-EM-ATN) algorithm on data acquired from 5 normal dogs and from simulated projection data using a homogeneous count-density model of a normal canine myocardium in the attenuation field measured in one dog. Mean counts in the S and L regions were calculated from maximum-count circumferential profile arrays. Our results demonstrate that ML-EM-ATN and Chang1 result in improved uniformity, as measured by the S/L ratio

Published in:

Nuclear Science Symposium and Medical Imaging Conference, 1994., 1994 IEEE Conference Record  (Volume:4 )

Date of Conference:

30 Oct-5 Nov 1994