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Healthcare data and medical information need to be seamlessly accessible and available at all times to the various healthcare stakeholders. Inability to share, integrate and access critical healthcare information is a challenge for the healthcare IT. Moreover, semantic interoperability of health-related heterogeneous data sources is a challenging issue and healthGrids are expected to address this challenge in a systematic manner. This paper proposes a new architecture: ASIDS (architecture for semantic integration of data sources), that could be a potential candidate for solving the challenge of semantic interoperability of geographically distributed heterogeneous data sources. ASIDS has three main components that are loosely coupled (through interfaces) in a distributed manner. This architecture sets the basis for future research in terms of implementing a healthGrid application in real environments.