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System integration is the basis to realize the business optimization and collaboration for manufacturing enterprises. To effectively improve the running efficiency of information systems and collaboration abilities with partners for manufacturing enterprises, this paper puts forward the conception of semantic framework model to solve the problems of semantic description, semantic mapping, semantic analysis and semantic routing in heterogeneous systems integration based on the analysis of presently system integration mode. Furthermore, the Semantic framework model-based intelligent information system integration mode for manufacturing enterprises is established and its integration operation processes are deeply studied which including semantic serviceable process for integration objects and dynamic intelligent integration process on demand. Finally, the integration mode is applied in a turbocharger manufacturing enterprise in Chongqing, and its feasibility is demonstrated.