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Microgap Structured Optical Sensor for Fast Label-Free DNA Detection

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3 Author(s)
Yunmiao Wang ; Virginia Polytech. Inst. & State Univ., Blacksburg, VA ; Cooper, K.L. ; Anbo Wang

This paper presents a new label-free DNA optical sensor based on the microgap structured Fabry-Perot interferometer. An optical cavity is formed by a microgap sealed between a singlemode fiber and a well-cleaved fiber end. The capture DNA is immobilized on the cavity end by layer-by-layer electrostatic self-assembly. This sensor detects the hybridization of target DNA with complementary capture DNA by observing the optical cavity thickness variation. Experimental results demonstrate that this sensor has a sensitivity of 6 nmol/ml and can identify a 2-bp mismatch.

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Lightwave Technology, Journal of  (Volume:26 ,  Issue: 17 )