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Manufacturing systems are complex and sophisticated. Modeling and simulation is effective for solving problems pertaining to these systems, such as the determination of the best configuration of a manufacturing system. Most simulation models of manufacturing systems adopt discrete-event simulation, an approach in which the continuous behavior of equipment in a spatial environment cannot be easily represented. In this paper, we present a hybrid simulation model that combine discrete-event and continuous simulation to deal with spatial and continuous state transitions. An event-state-operation transition diagram that can represent a simulation model is proposed. A simple example of manufacturing systems is modeled using the proposed approach and simulated through a transition diagram.