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The clinical symptoms of metabolic disorders are rarely apparent during the neonatal period, and if they are not treated early, irreversible damage, such as mental retardation, or even death, may occur. Therefore, the practice of newborn screening is important to the prevention of permanent disabilities in newborns.In this paper, we propose a newborn screening system that uses Support Vector Machine (SVM) classification techniques to evaluate raw data on the concentrations of metabolic substances obtained from tandem mass spectrometry (MS/MS) to determine if a newborn has a metabolic disorder. As per the concept of Service-Oriented Architecture (SOA), we designed the system using web services techniques, which are suitable for integrating heterogeneous platforms, protocols, and applications. It can be integrated seamlessly into National Taiwan University Hospital Information Systems (HIS) or other related HIS.