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Fe _{3} O _{4} Incorporated AOT-Alginate Nanoparticles for Drug Delivery

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9 Author(s)
Sudakar, C. ; Dept. of Phys. & Astron., Wayne State Univ., Detroit, MI ; Dixit, A. ; Regmi, R. ; Naik, R.
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Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe3O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ~50 emu/g of Fe3 O4. Similar behavior was exhibited by Fe2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

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Magnetics, IEEE Transactions on  (Volume:44 ,  Issue: 11 )