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Bead capture and release on a magnetic sensor in a microfluidic system

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5 Author(s)
Dalslet, B.T. ; Dept. of Micro & Nanotechnol., Tech. Univ. of Denmark, Lyngby ; Damsgaard, C.D. ; Freitasy, S.C. ; Freitas, S.C.
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Planar Hall effect magnetic sensors for detection of biological agents using surface treated magnetic beads are integrated with a fluid injection system. The response of the sensors is used to evaluate bead capture rates for different bead concentrations c and fluid flow rates Q, and to monitor subsequent removal of the beads. It is found that the capture rate scales directly with c and that it depends linearly on Q. At low Q the capture rate is only partially due to gravitational sedimentation of beads. At higher Q an additional term proportional to Q becomes important, which is attributed to capture of beads by the magnetic fields near the sensor. It is shown that beads can be washed off the sensor surface.

Published in:

Sensors, 2008 IEEE

Date of Conference:

26-29 Oct. 2008