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This work exploits the security management and the cooperation of applications in mobile distributed systems. In this context a reflection on different mobile middlewares is made: their capacities to face the challenges of mobility and security issues. The analyses show that the existing middlewares have very few approaches on security problems; security is still a complex issue to be managed in all the levels of a mobile distributed system including new mechanisms. Based on these analyses we propose a security management model that implements a mechanism of authentication, confidentiality and access control of mobile agents in total diffuse environment. The idea is based on interceptor agents and security authorities that distribute security tickets and control the access to resources and tuple spaces in mobile environment. The proposed model presents good performance and is integrated to an e-health system: relationship management with chronic patient GRPC.