By Topic

Parameter Identification for a DNA replication model

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Koutroumpas, K. ; Autom. Control Lab., ETH Zurich, Zurich ; Lygerou, Z. ; Lygeros, J.

DNA replication is one of the most fundamental processes in the life of every cell. In earlier work a model to capture the mechanics of the DNA replication process was developed. The model allowed us to make novel predictions regarding the mechanisms behind DNA replication based on experimental data for the fission yeast. One of the difficulties we had to overcome in the process was tuning of the model parameters based on experimental data, which, for lack of better methods had to be done manually. Here we propose a methodology for systematizing this process, inspired by techniques for multi-objective optimization.

Published in:

BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on

Date of Conference:

8-10 Oct. 2008