By Topic

Thinned ECOC Decomposition for Gene Expression Based Cancer Classification

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

1 Author(s)
Hatami, N. ; Dept. of Electr. Eng., Shahed Univ., Tehran

Cancer classification using gene expression data has the great importance in bioinformatics and is known to contain the keys for addressing the fundamental problems relating to cancer diagnosis and drug discovery. Error correcting output coding (ECOC) is a method to design multiple classifier systems (MCS), which reduces a multi-class problem into some binary sub-problem. A key issue in design of any ECOC ensemble is defining optimal code matrix with maximum discrimination power and minimum number of columns. This paper introduces a heuristic method for application dependent design of optimal ECOC matrix base on the thinning algorithm used in the ensemble design. The key idea of proposed method which called Thinned ECOC is to remove some redundant and unnecessary columns of any initial code matrix successively based on a metric defined for each column. Experimental results on two real datasets show the robustness of Thinned ECOC in comparison with the other existing code generation methods.

Published in:

Intelligent Systems Design and Applications, 2008. ISDA '08. Eighth International Conference on  (Volume:1 )

Date of Conference:

26-28 Nov. 2008