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In this paper, we present a transceiver design for a broadband multiuser-MIMO communication system, where the co-channel users are equipped with multiple transmit and multiple receive antennas. In particular, we propose a joint coded two-step interference cancellation scheme which effectively combats the effect of co-channel interference (CCI) and inter-symbol interference (ISI) in multipath channels. To overcome the peak-to-average-power ratio limitation of multicarrier systems, the scheme employs single-carrier frequency-domain equalization (SC-FDE) based modulation combined with time-reversed space-time block codes (TR-STBC). The receiver performs minimum mean-squared error (MMSE) interference suppression at the first stage, and then, CCI cancellation is implemented with a bank of single-user channel decoders. Also, forward error correction outer convolutional encoding, and random bit interleaving are used to correct the carrier in deep fades. To verify the utility of the proposed approach, the paper also includes two sets of average symbol error rate simulations for two different channel models. The first set is for a frequency selective quasi-static fading channel while the secondset is for a Rayleigh fading channel modeled by a modified Jakes' model, both of which confirm the advantage of the proposed scheme.