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A self-oscillating harmonic opto-electronic mixer based on a CMOS-compatible avalanche photodetector for fiber-fed 60-GHz self-heterodyne systems is demonstrated. The mixer is composed of an avalanche photodetector fabricated with 0.18-mum standard CMOS process and an electrical feedback loop for self oscillation. It simultaneously performs photodetection and frequency up-conversion of photodetected signals into the second harmonic self-oscillation frequency band. The avalanche photodetector and the mixer are characterized and analyzed, and the RF avalanche multiplication factor is investigated. In addition, conversion efficiency as well as internal conversion gain is determined, and bias conditions are optimized for the best self-oscillating harmonic opto-electronic mixer performance. Data transmission of 5-MS/s 32 quadrature amplitude modulation signals using self-oscillating harmonic opto-electronic mixer is successfully demonstrated.