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In this paper, a lead compensator is proposed for compensating round-trip delay of direct-sequence code-division multiple-access (DS-CDMA) cellular mobile radio systems. Furthermore, in addition to the delay compensation, a disturbance rejection filter is designed to minimize the effect of uncertain noise and interference to track a desired signal to interference and noise ratio (SINR). The two-step power control design is achieved by the H2 optimal approximation theory using the genetic algorithm. To confirm the performance of the proposed method, several simulation results are given in comparison with other methods.