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A new approach for diagnostic analysis of bandwidth mismatch in time-interleaved systems based on gradient search method is proposed. The algorithm is adaptive to slow changes in mismatch errors and does not require any information about the input signal. Additionally, the information acquired can be re-used to supplement the circuit calibration. The proposed method is evaluated on a prototype sample-and-hold circuit fabricated in standard single poly, five metal 0.18-mum CMOS.