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The third-generation partnership project (3GPP) specifies 3G-WLAN interworking that lets mobile stations (MSs) access 3G networks via WLAN-based packet data gateways (PDGs). The specification mandates that packets delivered between an MS and a PDG should be protected by IPsec. This article studies IPsec-based VoIP performance (in terms of throughput, packet loss rate, latency, and jitter) in the 3G-WLAN integration environment. The study is designed to provide guidelines for selecting appropriate system parameter values for VoIP over WLAN.