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Service-oriented architecture represents a promising approach to integrating data and software across different institutional and disciplinary sources, thus facilitating Web-scale collaboration while avoiding the need to convert different data and software to common formats. The US National Cancer Institute's Biomedical Information Grid program seeks to create both a service-oriented infrastructure (caGrid) and a suite of data and analytic services. Workflow tools in caGrid facilitate both the use and creation of services by accelerating service discovery, composition, and orchestration tasks. The authors present caGrid's workflow requirements and explain how they met these requirements by adopting and extending the Taverna system.