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The structural reliability is taken as control parameter for optimization design of structural engineering, and the computing is realized by Lingo that is nonlinear programming software. First, limit status function of structure is founded and the optimum algorithm for structural reliability is used as the constraint. Second, the program calculation is written by means of Lingo. Finally, the result indicates that computation from Lingo is accurate, high efficient and practical. It is very efficiency and convenience to make program of Lingo for optimization design based on reliability, and it is easy to be changed to calculation of other practice engineering and to be grasped for the engineers.