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Multimedia has been widely applied in life science research and clinical applications, including research on musculoskeletal system. Musculoskeletal disorders are the most notorious and common causes of severe long-term pain and physical disability, affecting hundreds of millions of people across the world. In the European Research Project 3D Anatomical Human (http:// 3dah.miralab.unige.ch/), we are building an accurate generic lower limb model that can be simulated in motion, using individual multimodal medical data. For clinical every-day use, medically relevant validation and an efficient visualization and interaction framework are required. We are defining a generic functional model of the lower limb (consisting of bones and soft-tissues) that can be simulated in motion. Relevant patientpsilas anatomical, kinematical and mechanical data extracted from images (MRI, CT), motion capture (dynamic MRI, optical motion capture) and other modalities (EMG, mechanical properties measuring device), as well as statistical data, are being adjust the generic model to the patient. A fully functional model will be presented with many individual cases study and medical validation.