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Information extracted from multiple channels of the surface myoelectric signal (MES) recording sites can be used as inputs to control systems for powered upper limb prostheses. For small, closely spaced muscles, such as the muscles in the forearm, the detected MES often contains contributions from more than one muscle, the contribution from each specific muscle being modified by the dispersive propagation through the volume conductor between the muscle and the detection points. In this paper, the measured raw MES signals are rotated by class-specific principal component matrices to spatially decorrelate the measured data prior to feature extraction. This ldquotunesrdquo the data to allow a pattern recognition classifier to better discriminate the test motions. This processing technique was used to significantly (p<0.01) reduce pattern recognition classification error for both intact limbed and transradial amputee subjects.