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This article deals with The National Center for Learning and Teaching in Nanoscale Science and Engineering to produce a new pardigm for classrooms. In addition, the NCLT has collaborated with nano-experts from academia and national laboratories throughout the United States. These teams are conducting learning research on the best approaches for the integration of NSE into the classroom and are contributing in several areas including learning progressions for nanoscience, establishing nanoconcept inventories and assessments, and research on the motivations of students towards learning nanoscience for grade 7 through college. The Center's operation is designed to rapidly integrate the latest nanoscience concepts into the classroom. To do this, the Center provides teacher training, nanocurriculum, and an interactive virtual resource portal.