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We propose an implementation of the tapped delay line adaptive array (TDLAA) at the base station for improving the BER performance of asynchronous multi-user in mobile communication over fast fading channels using multiple antennas. The data in each user at the mobile station, which applies two transmit antennas, are encoded by space time block code (STBC). The proposed scheme transmits the pilot signal and information data in alternate time slots. We derive performance criteria for designing such scheme under the assumption that fading is classified into fast fading condition. We show that our scheme can suppress co-channel interference (CCI) and defeat Doppler spread effectively.