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In this paper, a flexible and efficient time-domain method for calculating the bit error rate of high-speed differential links is presented. The method applies interpolation and superposition to the step response of a channel to construct the jittery data or/and clock waveforms at the receiver. With the statistics of the actual reference-crossing points extracted from the constructed receiver waveforms, the bathtub curves can be derived and extrapolated to get the eye margin at the given bit error rate. A software has been developed and applied for high-speed differential link design using the method. Good correlation has been achieved between the simulated results using this method and the measurement data with a bit error rate tester.