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Applications of optical resonance to biological imaging and label-free protein microarrays

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9 Author(s)
M. Selim Unlu ; Departments of Electrical and Computer Engineering, Physics and Biomedical Engineering at Boston University, MA 02215, USA ; I. E. Ozkumur ; J. Needham ; D. A. Bergstein
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We present biological imaging and sensing methods based on optical resonance and interference. In fluorescence microscopy, our nanoscale imaging capability sheds light onto conformational changes of DNA, DNA-protein complexes and polymer coatings on a solid surface. Interference measurements on a layered substrate yield a label-free sensing platform for protein binding in a high-throughput micro-array format.

Published in:

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Date of Conference:

20-25 Aug. 2008