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This paper presents the use of relevance feedback (RFb) to reduce the semantic gap in content-based image retrieval (CBIR) of mammographic masses. Tests were conducted where the radiologists' classification of the lesions based on the BI-RADS categories were used with techniques of query-point movement to incorporate RFb. The measures of similarity of images used for CBIR were based upon Zernike moments. The performance of CBIR was measured in terms of precision and recall of retrieval. The results indicate improvement due to RFb of up to 41.6% in precision. In our experiments, the gain in the performance of CBIR with RFb was associated with the BI-RADS category of the query mammographic image, with large improvement in cases of lesions belonging to categories 4 and 5. The proposed method could find applications in computer-aided diagnosis (CAD) of breast cancer.