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Network integration and graph analysis in mammalian molecular systems biology

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1 Author(s)
Ma'ayan, A. ; Dept. of Pharmacology & Syst. Therapeutics, Mount Sinai Sch. of Med., Mount Sinai, NY

Abstraction of intracellular biomolecular interactions into networks is useful for data integration and graph analysis. Network analysis tools facilitate predictions of novel functions for proteins, prediction of functional interactions and identification of intracellular modules. These efforts are linked with drug and phenotype data to accelerate drug-target and biomarker discovery. This review highlights the currently available varieties of mammalian biomolecular networks, and surveys methods and tools to construct, compare, integrate, visualise and analyse such networks.

Published in:

Systems Biology, IET  (Volume:2 ,  Issue: 5 )

Date of Publication:

September 2008

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