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Modulation of Conduction Velocity by Nonmyocytes in the Low Coupling Regime

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2 Author(s)
Jacquemet, V. ; Dept. of Biomed. Eng., Duke Univ., Durham, NC ; Henriquez, C.S.

This paper explores the conditions under which non myocytes, when electrically coupled to myocytes, act as a passive load during the depolarization phase. Using theoretical arguments and numerical simulations in a tissue incorporating fibroblasts, the passive load approximation is shown to be accurate at low coupling conductances ( <2 nS). In this case, the effect on conduction velocity can be expressed as a function of the elevation in resting potential and the coupling only.

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Biomedical Engineering, IEEE Transactions on  (Volume:56 ,  Issue: 3 )