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Suitability of Dysphonia Measurements for Telemonitoring of Parkinson's Disease

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5 Author(s)
Little, M.A. ; Syst. Anal., Modeling & Prediction Group, Univ. of Oxford, Oxford ; McSharry, P.E. ; Hunter, E.J. ; Spielman, J.
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In this paper, we present an assessment of the practical value of existing traditional and nonstandard measures for discriminating healthy people from people with Parkinson's disease (PD) by detecting dysphonia. We introduce a new measure of dysphonia, pitch period entropy (PPE), which is robust to many uncontrollable confounding effects including noisy acoustic environments and normal, healthy variations in voice frequency. We collected sustained phonations from 31 people, 23 with PD. We then selected ten highly uncorrelated measures, and an exhaustive search of all possible combinations of these measures finds four that in combination lead to overall correct classification performance of 91.4%, using a kernel support vector machine. In conclusion, we find that nonstandard methods in combination with traditional harmonics-to-noise ratios are best able to separate healthy from PD subjects. The selected nonstandard methods are robust to many uncontrollable variations in acoustic environment and individual subjects, and are thus well suited to telemonitoring applications.

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Biomedical Engineering, IEEE Transactions on  (Volume:56 ,  Issue: 4 )