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Mutual information (MI) has proven its effectiveness for automated multimodal image registration for numerous remote sensing applications like image fusion. We analyze MI performance with respect to joint histogram bin size and the employed joint histogramming technique. The affect of generalized partial volume estimation (GPVE) utilizing B-spline kernels with different histogram bin sizes on MI performance has been thoroughly explored for registration of high resolution SAR (TerraSAR-X) and optical (IKONOS-2) satellite images. Our experiments highlight possibility of an inconsistent MI behavior with different joint histogram bin size which gets reduced with an increase in order of B-spline kernel employed in GPVE. In general, bin size reduction and/or increasing B-spline order have a smoothing affect on MI surfaces and even the lowest order B-spline with a suitable histogram bin size can achieve same pixel level accuracy as achieved by the higher order kernels more consistently.