By Topic

A high frequency thickness shear mode (TSM) sensor for detection of biomarkers for prostate cancer

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Ergezen, E. ; Sch. of Biomed. Eng., Drexel Univ., Philadelphia, PA ; Hart, R.W. ; Philip, R. ; Lec, R.M.

A high frequency thickness shear mode (TSM) sensor was developed for detection of tumor-associated serum autoantibody biomarkers to diagnose prostate cancer early and to monitor effectiveness of treatment and recurrence of disease. The sensor response to three different proteins present in the cell lysate to their antibodies (W632, anti-plakoglobin and anti-EDDR1) were investigated using an array of TSM sensors operating at 100 MHz. The sensor exhibited the detection of all three biomarkers and detected differences in the concentration of the proteins in the lysate. The acoustic data was corroborated with a standard clinical test data (Western Blot). The obtained results clearly indicate that the proposed 100 MHz TSM sensor detection system is suitable for sensitive and selective multi-antigen assay platform for an autoantibody biomarker-based diagnostic screen for the early detection of prostate cancer.

Published in:

Frequency Control Symposium, 2008 IEEE International

Date of Conference:

19-21 May 2008